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Publication Date: 19 April 2017
Presenter(s): B Brett Finlay, PhD
Location: Columbus, OH, USA
We now realize that the eradication of microbes over the past century with the hygiene battle has unexpected consequences. Our war on microbes is having unforeseen consequences in increased rates of inflammatory bowel disease, mental health disorders, childhood obesity, and asthma. Dr Finlay reveals how asthma is associated with a specific gut microbiome signature at 3 months of age.
He further provides animal model evidence that both a malnourished diet, low in protein and fat, and specific microbes combine to contribute to the etiology of environmental enteropathy, a subclinical chronic inflammatory disease of the small intestine impacting the persistence of childhood malnutrition worldwide. Dr Finlay concludes that we must rethink our relationship with our microbes and establish a balance between hygiene and exposure to beneficial microbes.
PWIAS Distinguished Professor
Michael Smith Labs
University of British Columbia
Vancouver, BC, Canada
Dr B. Brett Finlay is a Professor in the Michael Smith Laboratories, and the Departments of Biochemistry and Molecular Biology, and Microbiology and Immunology at the University of British Columbia. He obtained a BSc (Honors) in Biochemistry at the University of Alberta, where he also did his PhD (1986) in Biochemistry under Dr William Paranchych, studying F-like plasmid conjugation. His post-doctoral studies were performed with Dr Stanley Falkow at the Department of Medical Microbiology and Immunology at Stanford University School of Medicine, where he studied Salmonella invasion into host cells. In 1989, he joined UBC as an Assistant Professor in the Biotechnology Laboratory.
Dr Finlay’s research interests are focused on host-microbe interactions at the molecular level. By combining cell biology with microbiology, he has been at the forefront of the field of Cellular Microbiology, making several fundamental discoveries in this area and publishing over 543 papers (h index=142). His laboratory studies several pathogenic bacteria, including Salmonella, pathogenic E. coli, and more recently, microbiota. He is well-recognized internationally for his work. He has won several prestigious awards, including the E.W.R. Steacie Prize, the CSM Fisher Scientific Award, the CSM Roche Award, an MRC Scientist, five Howard Hughes International Research Scholar Awards, a CIHR Distinguished Investigator, BC Biotech Innovation Award, the Michael Smith Health Research Prize, the IDSA Squibb award, the Jacob Biely Prize, the prestigious Canadian Killam Health Sciences Prize, the Flavelle Medal of the Royal Society, the Queen Elizabeth II Diamond Jubilee Medal, the Prix Galien, is a Fellow of the Royal Society of Canada and the Canadian Academy of Health Sciences, is a Member of the German National Academy of Sciences, the European Union Academy of Sciences, the American Academy of Microbiology, Chair d'État, Collège de France and is the UBC Peter Wall Distinguished Professor. He is an Officer of the Order of Canada and Order of British Columbia and inducted into the Canadian Medical Hall of Fame. He is a cofounder of Inimex Pharmaceuticals, Inc. and Microbiome Insights, scientific cofounder of Vedanta Pharmaceuticals and CommenSe, Director of the SARS Accelerated Vaccine Initiative, and Founding Director and Senior Fellow of CIFAR’s Microbes and Humans. He is also the co-author of the books Let Them Eat Dirt and The Whole Body Microbiome.
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