Courses

Measures to Identify Pediatric Malnutrition: Introduction to Mid-Upper Arm Circumference and Z-scores

How can pediatric malnutrition be accurately identified using mid-upper arm circumference (MUAC) and MUAC z-scores?

Presenter: Susan Abdel-Rahman, PharmD

Program Date: 12 February 2020

Publication Date: 14 May 2020

Continuing Education Credits: Nurse Contact 1.0 CE; Dietitian 1.0 CPEU

Course Description

Pediatric malnutrition is a common but often underrecognized condition across clinical and community settings, making early and accurate identification essential for timely intervention and improved health outcomes. Mid-upper arm circumferences (MUAC) and MUAC z-scores offer practical, reliable anthropometric tools for assessing nutritional status across infancy, childhood, and adolescence. 

MUAC has been used for decades and provides several advantages over weight- and height-based measures. It closely reflects lean body mass, predicts mortality risk, and is less affected by edema or acute fluid shifts, making it especially useful when traditional measurements are difficult to obtain or may be unreliable.

Historically, pediatric malnutrition screening has relied on fixed MUAC cutoff values, which can miss children with mild or moderate malnutrition—particularly in resource replete settings. Age- and sex-specific MUAC z-scores address these limitations by accounting for normal growth patterns and allowing more precise differentiation across levels of nutritional risk. Compared with percentiles, z-scores are especially informative at the extremes of nutritional status and support meaningful tracking of change over time.

When used alongside other indicators such as BMI-for-age or weight-for-length, MUAC z-scores provide complementary insight into body composition and nutritional risk. With appropriate training and standardized measurement techniques, MUAC assessment can be reliably applied in healthcare facilities and community settings, supporting earlier detection, improved caregiver engagement, and consistent monitoring of pediatric nutrition.

Course Objectives
  • Describe the validity of MUAC and its clinical application.
  • Review z-score calculations and how to interpret results in clinical practice.
  • Demonstrate how to accurately take MUAC measurements in pediatric practice.

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Key Takeaways
  • Mid-upper arm circumference is a strong predictor of mortality risk and more closely reflects lean body mass than many traditional anthropometric measures, making it especially useful when illness, edema, or measurement challenges limit the reliability of weight based indicators.
  • Fixed MUAC thresholds may fail to identify children with mild or moderate malnutrition, particularly in resource- replete settings where earlier detection could support intervention before severe outcomes develop.
  • Age- and sex-specific MUAC z-scores account for normal growth patterns and are more informative than percentiles at the extremes of nutritional status, supporting more accurate identification of risk and more meaningful tracking of change over time.
  • Dietitians, community health workers, and caregivers can reliably measure MUAC and interpret z-score ranges, improving early detection, caregiver engagement, and ongoing monitoring of pediatric nutritional status across diverse settings.

Performance Indicators: 9.2.3, 11.2.1, 11.2.6

Activity Code: 193226

Related Questions
  • How does mid-upper arm circumference (MUAC) compare with weight- and height-based measures for identifying pediatric malnutrition?
    MUAC has been shown to be a strong predictor of mortality risk and correlates more closely with lean body mass than weight- or height-based indicators. Unlike weight-for-age or BMI-for-age, MUAC is less affected by edema, ascites, or acute fluid shifts, making it particularly useful in children with illness or inflammation. These characteristics allow MUAC to identify nutritional risk that may not be apparent through traditional anthropometric measures alone.
  • Why are single MUAC cut-off values limited for detecting pediatric malnutrition?
    Fixed MUAC cut-off values do not account for normal age-related changes in arm circumference or sex differences, which can reduce sensitivity in detecting mild or moderate malnutrition. Evidence shows that reliance on a single threshold may miss children who are nutritionally compromised, particularly in resource-replete settings where earlier identification could support intervention before severe malnutrition develops.
  • What advantages do MUAC z-scores offer over percentiles when assessing nutritional status?
    MUAC z-scores express how far a child’s measurement deviates from the population mean while accounting for age and sex, allowing for consistent interpretation across the full range of nutritional status. Unlike percentiles, which compress values at the extremes, z-scores enable clearer tracking of clinically meaningful change over time. This makes MUAC z-scores particularly useful for monitoring improvement or decline in children at nutritional risk.
  • Can MUAC and MAUC z-scores be used reliably outside traditional clinical settings?
    With appropriate training and standardized measurement techniques, MUAC assessment can be reliably performed by dietitians, community health workers, and caregivers. Studies demonstrate high agreement between measurements taken in clinical settings and those obtained in community or home environments. Expanding MUAC assessment beyond healthcare facilities has been associated with earlier detection, improved caregiver engagement, and more consistent monitoring of pediatric nutritional status.

Course Instructor Bio(s)

Susan Abdel-Rahman, PharmD

Marion Merrell Dow/Missouri Chair
Pediatric Clinical Pharmacology
University of Missouri-Kansas City
Kansas City, MO, USA

Susan M Abdel-Rahman, PharmD, is a Professor of Pediatrics at the UMKC-School of Medicine, Director of Health Care Innovation for the Children’s Research Institute, Chief of the Section of Therapeutic Innovation, and Program Director for the NIH T32-funded fellowship in Pediatric Clinical Pharmacology at Children’s Mercy. Dr Abdel-Rahman came to Children’s Mercy after completing undergraduate and graduate training at Rutgers University and a post-doctoral fellowship at the Ohio State University. Dr Rahman has been involved in translational and clinical research for nearly 20 years with grants/contracts from the National Institutes of Health, US Food and Drug Administration, World Health Organization, Centers for Disease Control, National Endowment for the Arts, Pharmaceutical Industry and Private foundations. She directs a laboratory-based research program emphasizing analytical chemistry/molecular genetics and has overseen more than two dozen clinical studies, from small, single-site pharmacokinetic studies to large population-based epidemiologic investigations. Notably, Dr Rahman has enrolled over 28,000 participants into studies for which she served as the Principal Investigator. Dr Rahman leads a drug discovery program, is developing EHR-integrated precision therapeutics software, and has developed three medical devices, two of which have been cleared by the FDA (2015 & 2019). Dr Rahman is also an active member of the Clinical Pharmacology consult service, taking calls approximately 15 days per month. Dr Rahman chairs the Drug Utilization Review Board for the state of Missouri’s Medicaid program and currently serves as President-Elect for the American Society of Clinical Pharmacology and Therapeutics (ASCPT). She assumed the role of ASCPT President at the Annual Meeting in 2020.

Category
Highlighted References
  • Abdel-Rahman SM, Bi C, Thaete K. Construction of Lambda, Mu, Sigma Values for Determining Mid-Upper Arm Circumference z Scores in U.S. Children Aged 2 Months Through 18 Years. Nutr Clin Pract. 2017;32(1):68-76.
  • Bliss J, Lelijveld N, Briend A, et al. Use of Mid-Upper Arm Circumference by Novel Community Platforms to Detect, Diagnose, and Treat Severe Acute Malnutrition in Children: A Systematic Review. Glob Health Sci Pract. 2018;6(3):552-564. 
  • Miller MA, Mallory K, Escobedo M, Tarot AC, Abdel-Rahman S. Assessing effectiveness of a novel mid-upper arm circumference Z-score tape in a community setting in Guatemala. Arch Public Health. 2019;77:44. 
  • Myatt M, Khara T, Collins S. A review of methods to detect cases of severely malnourished children in the community for their admission into community-based therapeutic care programs. Food Nutr Bull. 2006;27(3 Suppl):S7-S23. 
  • Stephens K, Escobar A, Jennison EN, et al. Evaluating Mid-Upper Arm Circumference Z-Score as a Determinant of Nutrition Status. Nutr Clin Pract. 2018;33(1):124-132. 
  • World Health Organization, UNICEF. WHO child growth standards and the identification of severe acute malnutrition in infants and children: a Joint Statement. 2009. https://www.who.int/nutrition/publications/severemalnutrition/9789241598163/en/.

Additional Disclosures:

Funding from non-CPE revenue for CPE planning, development, review, and/or presentation has been provided by Abbott

Abbott Nutrition’s Provider Statement for Nursing CEs:

Abbott Nutrition Health Institute is an approved provider of continuing nursing education by the California Board of Registered Nursing Provider #CEP 11213.

Abbott Nutrition’s Statement for Dietitian CPEUs:

This educational activity has been prior-approved by the Commission on Dietetic Registration (CDR). CDR credentialed practitioners will receive the specified continuing professional education units (CPEUs) for completion of this program/material.